{"title":"Nausea \u0026 Vomiting","description":"","products":[{"product_id":"onseron-50ml-syrup-4mg-5ml","title":"Onseron 50ml Syrup 4mg\/5ml","description":"\u003cp\u003eOnseron 50ml Syrup 4mg\/5ml Specification\u003cbr\u003e\nRequires Prescription (YES\/NO)\u003cbr\u003e\nYes\u003c\/p\u003e\n\n\u003cp\u003eGenerics\u003cbr\u003e\nOndansetron\u003c\/p\u003e\n\n\u003cp\u003eUsed For\u003cbr\u003e\nNausea \u0026amp; Vomiting\u003c\/p\u003e\n\n\u003cp\u003eHow it works\u003cbr\u003e\nOndansetron is a selective antagonist of the serotonin receptor subtype, 5-HT3. Its precise mode of action in the control of chemotherapy induced nausea and vomiting is not known. Cytotoxic chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron may block the initiation of this reflex. Activation of vagal afferents may also cause a central release of serotonin from the chemoreceptor trigger zone of the area postrema, located on the floor of the fourth ventricle. Thus, the antiemetic effect of ondansetron is probably due to the selective antagonism of 5-HT3 receptors on neurons located in either the peripheral or central nervous systems, or both. The mechanisms of ondansetron's antiemetic action in post-operative nausea and vomiting are not known.\u003c\/p\u003e\n\n\u003cp\u003eUsage And Safety\u003cbr\u003e\nDosage\u003cbr\u003e\nThe recommended dose is : Adults and the elderly : During chemotherapy or radiotherapy : The usual dose is two 5ml spoonfuls (8mg ondansetron) ; This is taken 1 to 2 hours before your therapy starts; take two 5ml spoonfuls (8mg ondansetron) 12 hours later; take two 5ml spoonfuls (8mg ondansetron) twice a day for up to five days after the day of your chemo- or radiotherapy; if your chemotherapy is expected to make you feel, or be, very sick take 6 spoonfuls (24mg ondansetron) before therapy. Your doctor may recommend taking 12mg of dexamethasone at the same time; you should not take more than 32mg over a 24 hour period . Use in children and adolescents (aged 6 months and above) : During chemotherapy or radiotherapy : The dose depends on the weight or body surface area of the child; Your doctor will tell you the actual dose for your child;A dose range of half a 5ml spoonful (2mg ondansetron) to two 5 ml spoonfuls (8mg ondansetron) every 12 hours for up to five days is permitted OR As directed by your physician .\u003c\/p\u003e\n\n\u003cp\u003eSide Effects\u003cbr\u003e\nAdverse reactions observed when ondansetron is used for Chemotherapy induced Nausea and Vomiting Diarrhea, Headache, Fever, Constipation, Rash.Cardiovascular:Rare cases of angina (chest pain), electrocardiographic alterations, hypotension, and tachycardia, QT prolongation, ST segment depression, bradycardia.Hepatic: In comparative trials in cisplatin chemotherapy patients with normal baseline values of aspartate transaminase (AST) and alanine transaminase (ALT), these enzymes have been reported to exceed twice the upper limit of normal in approximately 5% of patients. The increases were transient and did not appear to be related to dose or duration of therapy. On repeat exposure, similar transient elevations in transaminase values occurred in some courses, but symptomatic hepatic disease did not occur.Neurological: There have been rare reports consistent with, but not diagnostic of, extrapyramidal reactions in patients receiving ondansetron Injection and rare cases of grand mal seizure.Other:Rare cases of hypokalemia.Adverse reactions observed when ondansetron is used for Postoperative Nausea and Vomiting Headache, Drowsiness\/sedation, Injection site reaction, Fever, Cold sensation, Pruritus and Paresthesia.OTHER ADVERSE REACTIONS:Local reactions:Pain, redness, burning at site of injectionLower respiratory: HiccupsSkin:Urticaria, Stenvens-Johnson syndrome, toxic epidermal necrolysis.Eye disorders:Transient blindnessNeurological:Oculogyric crisis, appearing alone,as well as with other dystonic reactions.Transient dizziness during or shortly after intervenous administration.\u003c\/p\u003e\n\n\u003cp\u003eDrug Interactions\u003cbr\u003e\nDrugs Affecting Cytochrome P-450 Enzymes , Apomorphine , Phenytoin, Carbamazepine, and Rifampin , Tramadol , Serotonergic Drugs , carmustine, etoposide, and cisplatin , Temazepam , Alfentanil and Atracurium.\u003c\/p\u003e\n\n\u003cp\u003eIndication\u003cbr\u003e\nPrevention of Nausea and Vomiting Associated with Initial and Repeat Courses of Emetogenic Cancer Chemotherapy.\u003c\/p\u003e\n\n\u003cp\u003eWhen not to Use\u003cbr\u003e\nOndansetron is contraindicated for patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Anaphylactic reactions may be observed in patients taking ondansetron.The concomitant use of apomorphine with ondansetron is contraindicated based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron.\u003c\/p\u003e\n\n\u003cp\u003ePrecautions\u003cbr\u003e\nPrecaution\u003cbr\u003e\nHypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.\u003c\/p\u003e\n\n\u003cp\u003eWarnings\u003cbr\u003e\nWarning 1\u003cbr\u003e\nOndansetron prolongs the QT interval in a dose-dependent manner . Avoid this medicine in patients with congenital long QT syndrome. ECG monitoring is recommended in patients with electrolyte abnormalities (e.g., hypokalemia or hypomagnesemia), congestive heart failure, bradyarrhythmias, or patients taking other medicinal products that lead to QT prolongation.\u003c\/p\u003e\n\n\u003cp\u003eWarning 2\u003cbr\u003e\nThe use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and gastric distention.\u003c\/p\u003e\n\n\u003cp\u003eWarning 3\u003cbr\u003e\nIt is not a drug that stimulates gastric or intestinal peristalsis. It should not be used instead of nasogastric suction.\u003c\/p\u003e\n\n\u003cp\u003eAdditional Information\u003cbr\u003e\nPregnancy category\u003cbr\u003e\nAlways consult your physician before using any medicine.\u003c\/p\u003e\n\n\u003cp\u003eStorage (YES\/NO)\u003cbr\u003e\nStore this medicine at room temperature, away from direct light and heat.\u003c\/p\u003e","brand":"Indus Pharma","offers":[{"title":"Default Title","offer_id":47654564823270,"sku":null,"price":460.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/6039\/1398\/files\/Onseron50mlSyrup.png?v=1781601610"},{"product_id":"onset-8mg-iv-im-injection-4ml-1-box-1-injection","title":"Onset 8mg Iv\/Im Injection 4ml (1 Box = 1 Injection)","description":"\u003cp\u003eMedicine\u003cbr\u003e\nBaby \u0026amp; Mother Care\u003cbr\u003e\nNutritions \u0026amp; Supplements\u003cbr\u003e\nFoods \u0026amp; Beverages\u003cbr\u003e\nDevices \u0026amp; Support\u003cbr\u003e\nPersonal Care\u003cbr\u003e\nOTC And Health Need\u003cbr\u003e\nHome\u003cbr\u003e\nMedicine\u003cbr\u003e\nNausea \u0026amp; Vomiting\u003cbr\u003e\nOnset 8mg Iv\/Im Injection 4ml (1 Box = 1 Injection)\u003c\/p\u003e\n\n\u003cp\u003eonset 8mg iv\/im injection 4ml (1 box = 1 injection) Product Image\u003cbr\u003e\nOnset 8mg Iv\/Im Injection 4ml (1 Box = 1 Injection)\u003cbr\u003e\nBrand : Pharmedic Laboratories\u003cbr\u003e\nRs. 230.85\u003cbr\u003e\nRs. 243.00\u003cbr\u003e\nPer Box\u003cbr\u003e\nDelivers in: Select Location\u003c\/p\u003e\n\n\u003cp\u003eADD TO CART\u003cbr\u003e\nSPECIFICATIONUSAGE AND SAFETYPRECAUTIONSWARNINGSADDITIONAL INFORMATION\u003cbr\u003e\nOnset 8mg Iv\/Im Injection 4ml (1 Box = 1 Injection) Specification\u003cbr\u003e\nRequires Prescription (YES\/NO)\u003cbr\u003e\nYes\u003c\/p\u003e\n\n\u003cp\u003eGenerics\u003cbr\u003e\nOndansetron\u003c\/p\u003e\n\n\u003cp\u003eUsed For\u003cbr\u003e\nNausea \u0026amp; Vomiting\u003c\/p\u003e\n\n\u003cp\u003eHow it works\u003cbr\u003e\nOndansetron is a selective antagonist of the serotonin receptor subtype, 5-HT3. Its precise mode of action in the control of chemotherapy induced nausea and vomiting is not known. Cytotoxic chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron may block the initiation of this reflex. Activation of vagal afferents may also cause a central release of serotonin from the chemoreceptor trigger zone of the area postrema, located on the floor of the fourth ventricle. Thus, the antiemetic effect of ondansetron is probably due to the selective antagonism of 5-HT3 receptors on neurons located in either the peripheral or central nervous systems, or both. The mechanisms of ondansetron's antiemetic action in post-operative nausea and vomiting are not known.\u003c\/p\u003e\n\n\u003cp\u003eUsage And Safety\u003cbr\u003e\nDosage\u003cbr\u003e\nPrevention of Nausea and Vomiting Associated with Initial and Repeat Courses of Emetogenic Chemotherapy: Ondansetron Injection should be diluted in 50 ml of 5% Dextrose Injection or 0.9% Sodium Chloride Injection before administration.Adults: The recommended adult intravenous dosage of Ondansetron is three 0.15-mg\/kg doses up to a maximum of 16 mg per dose. The first dose is infused over 15 minutes beginning 30 minutes before the start of emetogenic chemotherapy. Subsequent doses (0.15 mg\/kg up to a maximum of 16 mg per dose) are administered 4 and 8 hours after the first dose of Ondansetron.Pediatrics: For pediatric patients aged 6 months through 18 years, the intravenous dosage of Ondansetron is three 0.15-mg\/kg doses up to a maximum of 16 mg per dose. The first dose is to be administered 30 minutes before the start of moderately to highly emetogenic chemotherapy. Subsequent doses (0.15 mg\/kg up to a maximum of 16 mg per dose) are administered 4 and 8 hours after the first dose of Ondansetron. The drug should be infused intravenously over 15 minutes.Prevention of Postoperative Nausea and Vomiting: Ondansetron Injection should not be mixed with solutions for which physical and chemical compatibility have not been established. In particular, this applies to alkaline solutions as a precipitate may form.Adults: The recommended adult intravenous dosage of Ondansetron is 4 mg undiluted administered intravenously in not less than 30 seconds, preferably over 2 to 5 minutes, immediately before induction of anesthesia, or postoperatively if the patient did not receive prophylactic antiemetics and experiences nausea and\/or vomiting occurring within 2 hours after surgery. Alternatively, 4 mg undiluted may be administered intramuscularly as a single injection for adults. While recommended as a fixed dose for patients weighing more than 40 kg, few patients above 80 kg have been studied. In patients who do not achieve adequate control of postoperative nausea and vomiting following a single, prophylactic, preinduction, intravenous dose of ondansetron 4 mg, administration of a second intravenous dose of 4 mg ondansetron postoperatively does not provide additional control of nausea and vomiting.Pediatrics: For pediatric patients aged 1 month through 12 years, the dosage is a single 0.1-mg\/kg dose for patients weighing 40 kg or less, or a single 4-mg dose for patients weighing more than 40 kg. The rate of administration should not be less than 30 seconds, preferably over 2 to 5 minutes immediately prior to or following anesthesia induction, or postoperatively if the patient did not receive prophylactic antiemetics and experiences nausea and\/or vomiting occurring shortly after surgery. Prevention of further nausea and vomiting was only studied in patients who had not received prophylactic Ondansetron.\u003c\/p\u003e\n\n\u003cp\u003eSide Effects\u003cbr\u003e\nAdverse reactions observed when ondansetron is used for Chemotherapy induced Nausea and Vomiting Diarrhea, Headache, Fever, Constipation, Rash.Cardiovascular:Rare cases of angina (chest pain), electrocardiographic alterations, hypotension, and tachycardia, QT prolongation, ST segment depression, bradycardia.Hepatic: In comparative trials in cisplatin chemotherapy patients with normal baseline values of aspartate transaminase (AST) and alanine transaminase (ALT), these enzymes have been reported to exceed twice the upper limit of normal in approximately 5% of patients. The increases were transient and did not appear to be related to dose or duration of therapy. On repeat exposure, similar transient elevations in transaminase values occurred in some courses, but symptomatic hepatic disease did not occur.Neurological: There have been rare reports consistent with, but not diagnostic of, extrapyramidal reactions in patients receiving ondansetron Injection and rare cases of grand mal seizure.Other:Rare cases of hypokalemia.Adverse reactions observed when ondansetron is used for Postoperative Nausea and Vomiting Headache, Drowsiness\/sedation, Injection site reaction, Fever, Cold sensation, Pruritus and Paresthesia.OTHER ADVERSE REACTIONS:Local reactions:Pain, redness, burning at site of injectionLower respiratory: HiccupsSkin:Urticaria, Stenvens-Johnson syndrome, toxic epidermal necrolysis.Eye disorders:Transient blindnessNeurological:Oculogyric crisis, appearing alone,as well as with other dystonic reactions.Transient dizziness during or shortly after intervenous administration.\u003c\/p\u003e\n\n\u003cp\u003eDrug Interactions\u003cbr\u003e\nDrugs Affecting Cytochrome P-450 Enzymes , Apomorphine , Phenytoin, Carbamazepine, and Rifampin , Tramadol , Serotonergic Drugs , carmustine, etoposide, and cisplatin , Temazepam , Alfentanil and Atracurium.\u003c\/p\u003e\n\n\u003cp\u003eIndication\u003cbr\u003e\nPrevention of Nausea and Vomiting Associated with Initial and Repeat Courses of Emetogenic Cancer Chemotherapy.\u003c\/p\u003e","brand":"Pharmedic Laboratories","offers":[{"title":"Default Title","offer_id":47654564954342,"sku":null,"price":243.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/6039\/1398\/files\/Onset8mgIvImInjection4ml.png?v=1781601810"},{"product_id":"vomilux-60ml-suspension-5mg-5ml","title":"Vomilux 60ml Suspension 5mg\/5ml","description":"\u003cp\u003eVomilux 60ml Suspension 5mg\/5ml Specification\u003cbr\u003e\nRequires Prescription (YES\/NO)\u003cbr\u003e\nYes\u003c\/p\u003e\n\n\u003cp\u003eGenerics\u003cbr\u003e\nDomeperidone\u003c\/p\u003e\n\n\u003cp\u003eUsed For\u003cbr\u003e\nNausea \u0026amp; Vomiting\u003c\/p\u003e\n\n\u003cp\u003eHow it works\u003cbr\u003e\nIts anti emetic effect may be due to a combination of peripheral (gastrokinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood brain barrier in the area postrema.\u003c\/p\u003e\n\n\u003cp\u003eUsage And Safety\u003cbr\u003e\nDosage\u003cbr\u003e\nAdults : 10-20mg orally 3-4 times daily before meals , max 80mg daily. Re-evaluate need for continued treatment after 4 week. Children : Nausea \u0026amp; Vomiting - 0.25-0.5mg\/kg body-wt , 3-4 times daily, max 2.4mg\/kg daily. OR As directed by your physician.\u003c\/p\u003e\n\n\u003cp\u003eSide Effects\u003cbr\u003e\nDepression (2.5%) Anxiety (1.6%) Libido Decreased\/Loss of Libido , Headache (5.6%) , Somnolence (2.5%) , Akathisia (1%) , Diarrhea (5.2%) , Rash (2.8%), Pruritus (1.7%) , Breast Enlargement \/ Gynaecomastia (5.3%) Breast Tenderness (4.4%), Galactorrhoea (3.3%) , Amenorrhea (2.9%) , Breast Pain (2.3%), , Menstruation Irregular (2.0%) , Lactation Disorder (1.6%).\u003c\/p\u003e\n\n\u003cp\u003eDrug Interactions\u003cbr\u003e\nCYP3A4 inhibitors such as indinavir , Anti arrhythmics class IA (e.g., disopyramide, quinidine), anti arrhythmics class III (e.g., amiodarone, dofetilide, dronedarone, ibutilide, sotalol), certain antipsychotics (e.g., haloperidol, pimozide, sertindole), certain antidepressants (e.g., citalopram, escitalopram), certain antibiotics (e.g., levofloxacin, moxifloxacin), certain antifungal agents (e.g., pentamidine), certain antimalarial agents (e.g., halofantrine), certain gastro intestinal drugs (e.g., dolasetron), certain drugs used in cancer (e.g., toremifene, vandetanib), certain other drugs (e.g., bepridil, methadone).\u003c\/p\u003e\n\n\u003cp\u003eIndication\u003cbr\u003e\nIt is used in the treatment of nausea and vomiting.\u003c\/p\u003e\n\n\u003cp\u003eWhen not to Use\u003cbr\u003e\nDomeperidone is contraindicated in the following situations: • In patients with moderate to severe hepatic impairment • In patients who have known existing prolongation of cardiac conduction intervals (particularly QTc) and in patients with significant electrolyte disturbances or underlying cardiac diseases such as congestive heart failure.\u003c\/p\u003e\n\n\u003cp\u003ePrecautions\u003cbr\u003e\nPrecaution\u003cbr\u003e\nEpidemiological studies have shown domperidone may be associated with an increased risk of serious ventricular arrhythmias or sudden cardiac death.\u003c\/p\u003e\n\n\u003cp\u003eWarnings\u003cbr\u003e\nWarning 1\u003cbr\u003e\nPatients older than 60 years of age should consult their physician before taking domeperidone maleate.\u003c\/p\u003e\n\n\u003cp\u003eWarning 2\u003cbr\u003e\nDue to increased risk of ventricular arrhythmia, domeperidone maleate is not recommended in patients with known existing prolongation of cardiac conduction intervals, particularly QTc, in patients with significant electrolyte disturbances.\u003c\/p\u003e\n\n\u003cp\u003eWarning 3\u003cbr\u003e\nTreatment with domeperidone maleate should be stopped if signs or symptoms occur that may be associated with cardiac arrhythmia, and the patient should promptly consult their physician.\u003c\/p\u003e\n\n\u003cp\u003eAdditional Information\u003cbr\u003e\nPregnancy category\u003cbr\u003e\nAlways consult your physician before using any medicine.\u003c\/p\u003e\n\n\u003cp\u003eStorage (YES\/NO)\u003cbr\u003e\nStore this medicine at room temperature, away from direct light and heat.\u003c\/p\u003e","brand":"Atco Laboratories Limited","offers":[{"title":"Default Title","offer_id":47654565478630,"sku":null,"price":95.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/6039\/1398\/files\/Vomilux60mlSuspension.png?v=1781761697"},{"product_id":"ongene-tablets-8mg-1-box-1-strip1-strip-10-tablets","title":"Ongene Tablets 8mg (1 Box = 1 Strip)(1 Strip = 10 Tablets)","description":"\u003cp\u003eOngene Tablets 8mg (1 Box = 1 Strip)(1 Strip = 10 Tablets) Specification\u003cbr\u003e\nRequires Prescription (YES\/NO)\u003cbr\u003e\nYes\u003c\/p\u003e\n\n\u003cp\u003eGenerics\u003cbr\u003e\nOndansetron\u003c\/p\u003e\n\n\u003cp\u003eUsed For\u003cbr\u003e\nNausea \u0026amp; Vomiting\u003c\/p\u003e\n\n\u003cp\u003eHow it works\u003cbr\u003e\nOndansetron is a selective antagonist of the serotonin receptor subtype, 5-HT3. Its precise mode of action in the control of chemotherapy induced nausea and vomiting is not known. Cytotoxic chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron may block the initiation of this reflex. Activation of vagal afferents may also cause a central release of serotonin from the chemoreceptor trigger zone of the area postrema, located on the floor of the fourth ventricle. Thus, the antiemetic effect of ondansetron is probably due to the selective antagonism of 5-HT3 receptors on neurons located in either the peripheral or central nervous systems, or both. The mechanisms of ondansetron's antiemetic action in post-operative nausea and vomiting are not known.\u003c\/p\u003e\n\n\u003cp\u003eUsage And Safety\u003cbr\u003e\nDosage\u003cbr\u003e\nAdult: You may receive before and\/or after chemotherapy. The dose is between 8 and 24 mg a day (taken orally) for up to 5 days depending on the potential of your chemotherapy treatment to cause you to vomit and\/or have nausea. Children (4 to 12 years): After chemotherapy, take 4 mg orally every 8 hours for up to 5 days. Radiotherapy Induced Nausea and Vomiting Adult: Take 8 mg orally 1 to 2 hours before radiotherapy. After therapy, take 8 mg orally every 8 hours for up to 5 days after a course of treatment. Prevention of Post-Operative Nausea and Vomiting Adult: Take 16 mg orally one hour before anaesthesia. OR As directed by your physician .\u003c\/p\u003e\n\n\u003cp\u003eSide Effects\u003cbr\u003e\nAdverse reactions observed when ondansetron is used for Chemotherapy induced Nausea and Vomiting Diarrhea, Headache, Fever, Constipation, Rash.Cardiovascular:Rare cases of angina (chest pain), electrocardiographic alterations, hypotension, and tachycardia, QT prolongation, ST segment depression, bradycardia.Hepatic: In comparative trials in cisplatin chemotherapy patients with normal baseline values of aspartate transaminase (AST) and alanine transaminase (ALT), these enzymes have been reported to exceed twice the upper limit of normal in approximately 5% of patients. The increases were transient and did not appear to be related to dose or duration of therapy. On repeat exposure, similar transient elevations in transaminase values occurred in some courses, but symptomatic hepatic disease did not occur.Neurological: There have been rare reports consistent with, but not diagnostic of, extrapyramidal reactions in patients receiving ondansetron Injection and rare cases of grand mal seizure.Other:Rare cases of hypokalemia.Adverse reactions observed when ondansetron is used for Postoperative Nausea and Vomiting Headache, Drowsiness\/sedation, Injection site reaction, Fever, Cold sensation, Pruritus and Paresthesia.OTHER ADVERSE REACTIONS:Local reactions:Pain, redness, burning at site of injectionLower respiratory: HiccupsSkin:Urticaria, Stenvens-Johnson syndrome, toxic epidermal necrolysis.Eye disorders:Transient blindnessNeurological:Oculogyric crisis, appearing alone,as well as with other dystonic reactions.Transient dizziness during or shortly after intervenous administration.\u003c\/p\u003e\n\n\u003cp\u003eDrug Interactions\u003cbr\u003e\nDrugs Affecting Cytochrome P-450 Enzymes , Apomorphine , Phenytoin, Carbamazepine, and Rifampin , Tramadol , Serotonergic Drugs , carmustine, etoposide, and cisplatin , Temazepam , Alfentanil and Atracurium.\u003c\/p\u003e\n\n\u003cp\u003eIndication\u003cbr\u003e\nPrevention of Nausea and Vomiting Associated with Initial and Repeat Courses of Emetogenic Cancer Chemotherapy.\u003c\/p\u003e\n\n\u003cp\u003eWhen not to Use\u003cbr\u003e\nOndansetron is contraindicated for patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Anaphylactic reactions may be observed in patients taking ondansetron.The concomitant use of apomorphine with ondansetron is contraindicated based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron.\u003c\/p\u003e\n\n\u003cp\u003ePrecautions\u003cbr\u003e\nPrecaution\u003cbr\u003e\nHypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.\u003c\/p\u003e\n\n\u003cp\u003eWarnings\u003cbr\u003e\nWarning 1\u003cbr\u003e\nOndansetron prolongs the QT interval in a dose-dependent manner . Avoid this medicine in patients with congenital long QT syndrome. ECG monitoring is recommended in patients with electrolyte abnormalities (e.g., hypokalemia or hypomagnesemia), congestive heart failure, bradyarrhythmias, or patients taking other medicinal products that lead to QT prolongation.\u003c\/p\u003e\n\n\u003cp\u003eWarning 2\u003cbr\u003e\nThe use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and gastric distention.\u003c\/p\u003e\n\n\u003cp\u003eWarning 3\u003cbr\u003e\nIt is not a drug that stimulates gastric or intestinal peristalsis. It should not be used instead of nasogastric suction.\u003c\/p\u003e\n\n\u003cp\u003eAdditional Information\u003cbr\u003e\nPregnancy category\u003cbr\u003e\nAlways consult your physician before using any medicine.\u003c\/p\u003e\n\n\u003cp\u003eStorage (YES\/NO)\u003cbr\u003e\nStore this medicine at room temperature, away from direct light and heat.\u003c\/p\u003e","brand":"High-Q International.","offers":[{"title":"Default Title","offer_id":47654565544166,"sku":null,"price":380.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/6039\/1398\/files\/OngeneTablets8mg.png?v=1781595441"},{"product_id":"onseget-tablets-8mg-1-box-10-tablets","title":"Onseget Tablets 8mg (1 Box = 10 Tablets)","description":"\u003cp\u003eOnseget Tablets 8mg (1 Box = 10 Tablets) Specification\u003cbr\u003e\nRequires Prescription (YES\/NO)\u003cbr\u003e\nYes\u003c\/p\u003e\n\n\u003cp\u003eGenerics\u003cbr\u003e\nOndansetron\u003c\/p\u003e\n\n\u003cp\u003eUsed For\u003cbr\u003e\nNausea \u0026amp; Vomiting\u003c\/p\u003e\n\n\u003cp\u003eHow it works\u003cbr\u003e\nOndansetron is a selective antagonist of the serotonin receptor subtype, 5-HT3. Its precise mode of action in the control of chemotherapy induced nausea and vomiting is not known. Cytotoxic chemotherapy and radiotherapy are associated with the release of serotonin (5-HT) from enterochromaffin cells of the small intestine, presumably initiating a vomiting reflex through stimulation of 5-HT3 receptors located on vagal afferents. Ondansetron may block the initiation of this reflex. Activation of vagal afferents may also cause a central release of serotonin from the chemoreceptor trigger zone of the area postrema, located on the floor of the fourth ventricle. Thus, the antiemetic effect of ondansetron is probably due to the selective antagonism of 5-HT3 receptors on neurons located in either the peripheral or central nervous systems, or both. The mechanisms of ondansetron's antiemetic action in post-operative nausea and vomiting are not known.\u003c\/p\u003e\n\n\u003cp\u003eUsage And Safety\u003cbr\u003e\nDosage\u003cbr\u003e\nAdult: You may receive before and\/or after chemotherapy. The dose is between 8 and 24 mg a day (taken orally) for up to 5 days depending on the potential of your chemotherapy treatment to cause you to vomit and\/or have nausea. Children (4 to 12 years): After chemotherapy, take 4 mg orally every 8 hours for up to 5 days. Radiotherapy Induced Nausea and Vomiting Adult: Take 8 mg orally 1 to 2 hours before radiotherapy. After therapy, take 8 mg orally every 8 hours for up to 5 days after a course of treatment. Prevention of Post-Operative Nausea and Vomiting Adult: Take 16 mg orally one hour before anaesthesia. OR As directed by your physician .\u003c\/p\u003e\n\n\u003cp\u003eSide Effects\u003cbr\u003e\nAdverse reactions observed when ondansetron is used for Chemotherapy induced Nausea and Vomiting Diarrhea, Headache, Fever, Constipation, Rash.Cardiovascular:Rare cases of angina (chest pain), electrocardiographic alterations, hypotension, and tachycardia, QT prolongation, ST segment depression, bradycardia.Hepatic: In comparative trials in cisplatin chemotherapy patients with normal baseline values of aspartate transaminase (AST) and alanine transaminase (ALT), these enzymes have been reported to exceed twice the upper limit of normal in approximately 5% of patients. The increases were transient and did not appear to be related to dose or duration of therapy. On repeat exposure, similar transient elevations in transaminase values occurred in some courses, but symptomatic hepatic disease did not occur.Neurological: There have been rare reports consistent with, but not diagnostic of, extrapyramidal reactions in patients receiving ondansetron Injection and rare cases of grand mal seizure.Other:Rare cases of hypokalemia.Adverse reactions observed when ondansetron is used for Postoperative Nausea and Vomiting Headache, Drowsiness\/sedation, Injection site reaction, Fever, Cold sensation, Pruritus and Paresthesia.OTHER ADVERSE REACTIONS:Local reactions:Pain, redness, burning at site of injectionLower respiratory: HiccupsSkin:Urticaria, Stenvens-Johnson syndrome, toxic epidermal necrolysis.Eye disorders:Transient blindnessNeurological:Oculogyric crisis, appearing alone,as well as with other dystonic reactions.Transient dizziness during or shortly after intervenous administration.\u003c\/p\u003e\n\n\u003cp\u003eDrug Interactions\u003cbr\u003e\nDrugs Affecting Cytochrome P-450 Enzymes , Apomorphine , Phenytoin, Carbamazepine, and Rifampin , Tramadol , Serotonergic Drugs , carmustine, etoposide, and cisplatin , Temazepam , Alfentanil and Atracurium.\u003c\/p\u003e\n\n\u003cp\u003eIndication\u003cbr\u003e\nPrevention of Nausea and Vomiting Associated with Initial and Repeat Courses of Emetogenic Cancer Chemotherapy.\u003c\/p\u003e\n\n\u003cp\u003eWhen not to Use\u003cbr\u003e\nOndansetron is contraindicated for patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Anaphylactic reactions may be observed in patients taking ondansetron.The concomitant use of apomorphine with ondansetron is contraindicated based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron.\u003c\/p\u003e\n\n\u003cp\u003ePrecautions\u003cbr\u003e\nPrecaution\u003cbr\u003e\nHypersensitivity reactions, including anaphylaxis and bronchospasm, have been reported in patients who have exhibited hypersensitivity to other selective 5-HT3 receptor antagonists.\u003c\/p\u003e\n\n\u003cp\u003eWarnings\u003cbr\u003e\nWarning 1\u003cbr\u003e\nOndansetron prolongs the QT interval in a dose-dependent manner . Avoid this medicine in patients with congenital long QT syndrome. ECG monitoring is recommended in patients with electrolyte abnormalities (e.g., hypokalemia or hypomagnesemia), congestive heart failure, bradyarrhythmias, or patients taking other medicinal products that lead to QT prolongation.\u003c\/p\u003e\n\n\u003cp\u003eWarning 2\u003cbr\u003e\nThe use of ondansetron in patients following abdominal surgery or in patients with chemotherapy-induced nausea and vomiting may mask a progressive ileus and gastric distention.\u003c\/p\u003e\n\n\u003cp\u003eWarning 3\u003cbr\u003e\nIt is not a drug that stimulates gastric or intestinal peristalsis. It should not be used instead of nasogastric suction.\u003c\/p\u003e\n\n\u003cp\u003eAdditional Information\u003cbr\u003e\nPregnancy category\u003cbr\u003e\nAlways consult your physician before using any medicine.\u003c\/p\u003e\n\n\u003cp\u003eStorage (YES\/NO)\u003cbr\u003e\nStore this medicine at room temperature, away from direct light and heat.\u003c\/p\u003e","brand":"Getz Pharma Pakistan","offers":[{"title":"Default Title","offer_id":47654565609702,"sku":null,"price":400.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/6039\/1398\/files\/OnsegetTablets8mg.png?v=1781601279"}],"url":"https:\/\/www.glitzson.com\/collections\/nausea-vomiting.oembed","provider":"Glitzson","version":"1.0","type":"link"}