{"product_id":"ascard-plus-tablets-75-75mg-1-box-1-strip1-strip-10-tablets","title":"Ascard Plus Tablets 75\/75mg (1 Box = 1 Strip)(1 Strip = 10 Tablets)","description":"\u003cdiv id=\"SPECIFICATION\" class=\"productDescription_descriptionWrapper2__mjUHQ\"\u003e\n\u003ch2 class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__lpzz8 css-9l3uo3\"\u003eAscard Plus Tablets 75\/75mg (1 Box = 1 Strip)(1 Strip = 10 Tablets) Specification\u003c\/h2\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eRequires Prescription (YES\/NO)\u003c\/h3\u003e\n\u003cp\u003eYes\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eGenerics\u003c\/h3\u003e\n\u003cp\u003eAspirin, Clopidogrel\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eUsed For\u003c\/h3\u003e\n\u003cp\u003eStroke\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eHow it works\u003c\/h3\u003e\n\u003cp\u003eClopidogrel is an inhibitor of platelet activation and aggregation through the irreversible binding of its active metabolite to the P2Y12 class of ADP receptors on platelets. Aspirin inhibits prostaglandin synthesis resulting in inhibition of platelet aggregation for their lifespan of about 7-10 days. The acetyl group of aspirin binds with a serine residue of cyclooxygenase-1 (COX-1), resulting in irreversible inactivation of the enzyme. Inhibition of COX-1 prevents conversion of arachidonic acid to thromboxane A2 (TXA2), which is a potent agonist of platelet aggregation.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"USAGE AND SAFETY\" class=\"productDescription_descriptionWrapper2__mjUHQ\"\u003e\n\u003ch2 class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__lpzz8 css-9l3uo3\"\u003eUsage And Safety\u003c\/h2\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eDosage\u003c\/h3\u003e\n\u003cp\u003eOral : Adults : 1 Tablet once daily. Always consult your doctor or Pharmacist for dose adjustment.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eSide Effects\u003c\/h3\u003e\n\u003cp\u003eUncommon: Thrombocytopenia, leucopenia, eosinophiliaRare: Neutropenia, including severe neutropeniaVery rare: Thrombotic thrombocytopenic purpura (TTP), aplastic anaemia, pancytopenia, agranulocytosis, severe thrombocytopenia, acquired haemophilia A, granulocytopenia, anaemia\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eDrug Interactions\u003c\/h3\u003e\n\u003cp\u003eOral anticoagulants , Heparin , Thrombolytics , NSAIDs , SSRIs . Clopidogrel : Inducers of CYP2C19 , Inhibitors of CYP2C19 , Proton Pump Inhibitors (PPI) , Anti-retroviral therapies (ART) . Aspirin : Uricosurics (benzbromarone, probenecid, sulfinpyrazone) , Methotrexate , Tenofovir , Valproic acid , Alcohol.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eIndication\u003c\/h3\u003e\n\u003cp\u003eIt is indicated for the prevention of ischemic events, myocardial infarction, stroke and cardiovascular death in patients with Acute Coronary Syndrome (ACS).\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eWhen not to Use\u003c\/h3\u003e\n\u003cp\u003eDue to the presence of both components of the medicinal product, Clopidogrel\/Aspirin is contraindicated in case of:• Hypersensitivity to the active substances or to any of the excipients.• Severe hepatic impairment.• Active pathological bleeding such as peptic ulcer or intracranial haemorrhage\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"PRECAUTIONS\" class=\"productDescription_descriptionWrapper2__mjUHQ\"\u003e\n\u003ch2 class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__lpzz8 css-9l3uo3\"\u003ePrecautions\u003c\/h2\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003ePrecaution\u003c\/h3\u003e\n\u003cp\u003eDue to the risk of bleeding and haematological adverse reactions, blood cell count determination and\/or other appropriate testing should be promptly considered whenever clinical symptoms suggestive of bleeding arise during the course of treatment.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"WARNINGS\" class=\"productDescription_descriptionWrapper2__mjUHQ\"\u003e\n\u003ch2 class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__lpzz8 css-9l3uo3\"\u003eWarnings\u003c\/h2\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eWarning 1\u003c\/h3\u003e\n\u003cp\u003ePatients should be followed carefully for any signs of bleeding including occult bleeding, especially during the first weeks of treatment and\/or after invasive cardiac procedures or surgery. The concomitant administration of Clopidogrel\/Aspirin with oral anticoagulants is not recommended since it may increase the intensity of bleeding.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eWarning 2\u003c\/h3\u003e\n\u003cp\u003eAcquired haemophilia has been reported following use of clopidogrel. In cases of confirmed isolated activated Partial Thromboplastin Time (aPTT) prolongation with or without bleeding, acquired haemophilia should be considered. Patients with a confirmed diagnosis of acquired haemophilia should be managed and treated by specialists, and clopidogrel should be discontinued.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eWarning 3\u003c\/h3\u003e\n\u003cp\u003eIn patients with recent transient ischaemic attack or stroke who are at high risk of recurrent ischaemic events, the combination of ASA and clopidogrel has been shown to increase major bleeding. Therefore, such addition should be undertaken with caution outside of clinical situations where the combination has proven to be beneficial.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e\n\u003cdiv id=\"ADDITIONAL INFORMATION\" class=\"productDescription_descriptionWrapper2__mjUHQ\"\u003e\n\u003ch2 class=\"MuiTypography-root MuiTypography-body1 productDescription_productTitle__lpzz8 css-9l3uo3\"\u003eAdditional Information\u003c\/h2\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003ePregnancy category\u003c\/h3\u003e\n\u003cp\u003eAlways consult your physician before using any medicine.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003cdiv class=\"productDescription_descriptionWrapper3___ZqGB\"\u003e\n\u003ch3 class=\"MuiTypography-root MuiTypography-body1 productDescription_productSubTitle__y_nDL css-9l3uo3\"\u003eStorage (YES\/NO)\u003c\/h3\u003e\n\u003cp\u003eStore this medicine at room temperature, away from direct light and heat.\u003c\/p\u003e\n\u003c\/div\u003e\n\u003c\/div\u003e","brand":"Atco Laboratories Limited","offers":[{"title":"Default Title","offer_id":47897173360870,"sku":null,"price":290.0,"currency_code":"PKR","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0801\/6039\/1398\/files\/ASCARDPLUS.png?v=1781687847","url":"https:\/\/www.glitzson.com\/products\/ascard-plus-tablets-75-75mg-1-box-1-strip1-strip-10-tablets","provider":"Glitzson","version":"1.0","type":"link"}