{"product_id":"oris-1mg-tab-10tab-in-box","title":"ORIS 1MG TAB (10TAB IN BOX)","description":"\u003cp\u003e\u003cspan\u003eORIS Tablets (1 Strip = 10 Tablets) Specification\u003cbr\u003eRequires Prescription (YES\/NO)\u003cbr\u003eYes\u003cbr\u003e\u003cbr\u003eGenerics\u003cbr\u003eRisperidone\u003cbr\u003e\u003cbr\u003eUsed For\u003cbr\u003eSchizophrenia\u003cbr\u003e\u003cbr\u003eHow it works\u003cbr\u003eThe mechanism of action of risperidone in schizophrenia is unclear. The drug’s therapeutic activity in schizophrenia could be mediated through a combination of dopamine Type 2 (D2) and serotonin Type 2 (5HT2) receptor antagonism. The clinical effect from risperidone results from the combined concentrations of risperidone and its major metabolite, 9-hydroxyrisperidone (paliperidone). Antagonism at receptors other than D2 and 5HT2 may explain some of the other effects of risperidone.\u003cbr\u003e\u003cbr\u003eUsage And Safety\u003cbr\u003eDosage\u003cbr\u003eSchizophrenia: Adults - Over 15yr , day one , 1mg twice daily , day two , 2mg twice daily , day three 3mg twice daily . Max 8mg twice daily. Elderly : Initially 0.5mg twice daily increasing in 0.5mg increments to 1-2mg twice daily. Always consult your doctor or pharmacist for dose adjustment.\u003cbr\u003e\u003cbr\u003eSide Effects\u003cbr\u003e• Increased mortality in elderly patients with dementia-related psychosis • Cerebrovascular adverse events, including stroke, in elderly patients with dementia-related psychosis • Neuroleptic malignant syndrome • Tardive dyskinesia • Metabolic Changes (Hyperglycemia and diabetes mellitus, Dyslipidemia, and Weight Gain) • Hyperprolactinemia • Orthostatic hypotension • Falls • Leukopenia, neutropenia, and agranulocytosis • Potential for cognitive and motor impairment • Seizures • Dysphagia • Priapism • Disruption of body temperature regulation • Patients with Phenylketonuria .\u003cbr\u003e\u003cbr\u003eDrug Interactions\u003cbr\u003eFluoxetine , Paroxetine , Carbamazepine , Ranitidine , Cimetidine , Erythromycin , Amitriptyline , levodopa , ketoconazole , verapamil , furoseamide , paliperidone , dopamine agonists , rifampicin , anticholinergics.\u003cbr\u003e\u003cbr\u003eIndication\u003cbr\u003eIt (risperidone) is indicated for the treatment of schizophrenia.\u003cbr\u003e\u003cbr\u003eWhen not to Use\u003cbr\u003eIt is contraindicated in patients with a known hypersensitivity to either risperidone or paliperidone, or to any of the excipients in the formulation. Hypersensitivity reactions, including anaphylactic reactions and angioedema, have been reported in patients treated with risperidone and in patients treated with paliperidone. Paliperidone is a metabolite of risperidone.\u003cbr\u003e\u003cbr\u003ePrecautions\u003cbr\u003ePrecaution\u003cbr\u003eElderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.\u003cbr\u003e\u003cbr\u003eWarnings\u003cbr\u003eWarning 1\u003cbr\u003eNeuroleptic Malignant Syndrome (NMS), a potentially fatal symptom complex, has been reported in association with antipsychotic drugs.\u003cbr\u003e\u003cbr\u003eWarning 2\u003cbr\u003eTardive dyskinesia, a syndrome consisting of potentially irreversible, involuntary, dyskinetic movements, may develop in patients treated with antipsychotic drugs.\u003cbr\u003e\u003cbr\u003eWarning 3\u003cbr\u003eAtypical antipsychotic drugs have been associated with metabolic changes that may increase cardiovascular\/cerebrovascular risk. These metabolic changes include hyperglycemia, dyslipidemia, and body weight gain. While all of the drugs in the class have been shown to produce some metabolic changes, each drug has its own specific risk profile .\u003cbr\u003e\u003cbr\u003eAdditional Information\u003cbr\u003ePregnancy category\u003cbr\u003eAlways consult your physician before using any medicine.\u003cbr\u003e\u003cbr\u003eStorage (YES\/NO)\u003cbr\u003eStore this medicine at room temperature, away from direct light and heat.\u003c\/span\u003e\u003c\/p\u003e","brand":"SHAWAN PHARMACEUTICALS","offers":[{"title":"Default Title","offer_id":47900933456102,"sku":null,"price":180.0,"currency_code":"PKR","in_stock":true}],"url":"https:\/\/www.glitzson.com\/products\/oris-1mg-tab-10tab-in-box","provider":"Glitzson","version":"1.0","type":"link"}