Dermovate-Nn Ointment 20g

Dermovate-NN Ointment 20g – Uses, Dosage, Side Effects & Safety Information
Prescription Requirement

Yes – Prescription Only Medicine

Generic Composition

Clobetasol Propionate – Super-potent topical corticosteroid

Neomycin Sulphate – Broad-spectrum aminoglycoside antibiotic

Nystatin – Antifungal agent active against Candida species

Drug Class

Topical Corticosteroid + Antibiotic + Antifungal Combination

What is Dermovate-NN Ointment Used For?

Dermovate-NN Ointment is a triple-action topical medication used to treat severe inflammatory skin conditions complicated by bacterial or fungal infection. It is especially effective in infected eczema and infected psoriasis, where inflammation, bacterial growth, and fungal overgrowth may occur simultaneously.

Indications

Dermovate-NN Ointment is indicated for:

Eczema with secondary infection

Psoriasis with suspected bacterial or candidal infection

Steroid-responsive dermatoses at risk of infection

Severe inflammatory skin conditions where antibacterial and antifungal coverage is required

How Dermovate-NN Ointment Works

Clobetasol propionate suppresses inflammation by activating glucocorticoid receptors, leading to reduced redness, swelling, itching, and immune response in the skin. It also causes vasoconstriction and reduces collagen synthesis.

Neomycin sulphate provides broad-spectrum antibacterial activity against susceptible bacteria.

Nystatin delivers targeted antifungal action against Candida species.

Together, these components provide anti-inflammatory, antibacterial, and antifungal protection, making Dermovate-NN suitable for inflamed skin conditions that are infected or likely to become infected.

Dosage and Administration

Adults:
Apply a thin layer to the affected area once or twice daily.

Maximum: 50 g per week

Duration: Up to 4 weeks, then medical review required

Children:
Same dosage as adults, but weekly clinical monitoring is essential.

⚠️ Use strictly as prescribed by your physician.

Possible Side Effects
Common (≤1 in 10 people)

Skin thinning

Increased visibility of veins under the skin

Uncommon (≤1 in 100 people)

Stretch marks (striae)

Very Rare (≤1 in 10,000 people)

Increased risk of skin infections

Allergic skin reactions at application site

Burning, pain, itching, or irritation

Rash, redness, or itchy raised bumps

Dry, fragile, wrinkled skin

Changes in skin colour

Increased or decreased hair growth, hair loss

Weight gain and rounding of the face (Cushingoid features)

Slowed growth or delayed weight gain in children

Bone thinning or fractures

Eye disorders such as cataract or glaucoma

Raised blood sugar levels

High blood pressure

Drug Interactions

Use with caution when combined with:

CYP3A4 inhibitors (e.g. ritonavir, itraconazole)

Systemic aminoglycoside antibiotics

Neuromuscular blocking agents

These may increase systemic absorption or toxicity.

When Not to Use Dermovate-NN Ointment

Do not use this medicine if:

You are allergic to clobetasol, neomycin, or nystatin

The patient is under 2 years of age

You are treating:

Acne

Rosacea

Perioral dermatitis

Genital or anal itching (unless advised by a doctor)

Viral infections (herpes, chickenpox, cold sores)

Fungal infections such as ringworm or athlete’s foot

Infected skin blisters or sores

Outer ear infections with a perforated eardrum

Precautions

Prolonged use of topical antibiotics may rarely cause pseudomembranous colitis

If persistent diarrhoea or abdominal cramps occur, discontinue use and seek medical advice

Avoid long-term use, especially on large body areas or under occlusive dressings

Warnings

Stop treatment immediately if signs of local hypersensitivity appear

Avoid use on the face; if necessary, limit to a few days only

Exercise caution when applying near the eyes or eyelids to prevent cataract or glaucoma

If the ointment enters the eye, rinse thoroughly with clean water

Use During Pregnancy & Breastfeeding

⚠️ Consult your doctor before use.
Use only if the expected benefit outweighs potential risk.

Storage Instructions

Yes – Store at room temperature, protected from direct heat, light, and moisture.
Keep out of reach of children.