Sumatec Tablets 50mg (1 Box = 1 Strip)(1 Strip = 2 Tablets)

Sumatriptan has been demonstrated to be a selective vascular 5-hydroxytryptamine-1-(5-HT 1D) receptor agonist with no effect at other 5-HT receptor (5-HT2–7) subtypes. The vascular 5-HT 1D receptor is found predominantly in cranial blood vessels and mediates vasoconstriction. In animals, sumatriptan selectively constricts the carotid arterial circulation, but does not alter cerebral blood flow. The carotid arterial circulation supplies blood to the extracranial and intracranial tissues such as the meninges and dilatation and/or oedema formation in these vessels is thought to be the underlying mechanism of migraine in man. In addition, experimental evidence suggests that sumatriptan inhibits trigeminal nerve activity. Both these actions may contribute to the anti-migraine action of sumatriptan in humans.