Xedexo 6mg 25mg Capsules PACK OF 14
Xedexo 6mg 25mg Capsules PACK OF 14
Xedexo Capsules 6mg/25mg (1 Box = 2 Strips) (1 Strip = 7 Capsules) Specification
Requires Prescription (YES/NO)
Yes
Generics
Olanzapine , Fluoxetine
Used For
Depression
How it works
Fluoxetine: Inhibits CNS neuron setotonin reuptake with minimal or no effect on norepinephrine or dopamine reuptake; does not bind to alpha-adrenergic, histamine, or cholinergic receptors Olanzapine: Potent antagonist of dopamine 1-3, histamine H1, serotonin 5-HT2A and 5-HT2C, and alpha1-adrenergic receptors; shows moterate antagonism for 5-HT3, and muscarinic M1-5 receptors; binds to GABA-A, benzodiazepine, and beta-adrenergic receptors .
Usage And Safety
Dosage
Depression Associated with Bipolar I Disorder : Initial: 25 mg/6 mg orally daily in evening . If needed, may titrate with 25-50 mg fluoxetine/6-12 mg olanzapine; not to exceed 75 mg/18 mg per day . Treatment of Resistant Depression : Initial: 25 mg/6 mg orally daily in evening . If needed, may titrate with 25-50 mg fluoxetine/6-12 mg olanzapine; not to exceed 75 mg/18 mg per day . Hypotensive diathesis, hepatic impairment, or slow metabolism: Initiate with 25 mg/3 mg to 25 mg/6 mg orally every day . OR As directed by your physician.
Side Effects
Chills, neck rigidity, photosensitivity reaction ,vasodilatation , QT-interval prolonged , diarrhea , gastritis, gastroenteritis, nausea and vomiting, peptic ulcer , gastrointestinal hemorrhage, intestinal obstruction, liver fatty deposit, pancreatitis , ecchymosis , anemia, thrombocytopenia , leukopenia, purpura , generalized edema, weight loss , bilirubinemia, creatinine increased, gout , osteoporosis .
Drug Interactions
Monoamine Oxidase Inhibitors (MAOI) , CNS Acting Drugs , Serotonergic Drugs , Triptans , Tryptophan , Drugs that Interfere with Hemostasis (e.g., NSAIDs, Aspirin, Warfarin) , Benzodiazepines , Inducers of 1A2 , Inhibitors of CYP1A2 , Pimozide , Carbamazepine , Thioridazine , Tricyclic Antidepressants (TCAs) , Antihypertensive Agents , Levodopa and Dopamine Agonists , Benzodiazepines , Clozapine , Haloperidol , Phenytoin , Lithium , Drugs Tightly Bound to Plasma Proteins , Valproate , Biperiden , Theophylline .
Indication
Depressive Episodes Associated with Bipolar I Disorder : It is indicated for the acute treatment of depressive episodes associated with Bipolar I Disorder in adults ; Treatment Resistant Depression : It is indicated for the acute treatment of treatment resistant depression (Major Depressive Disorder in adults who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode).
When not to Use
The use is contraindicated with the following: • Monoamine Oxidase Inhibitors (MAOI) • Pimozide • Thioridazine •Hypersensitive to any of the ingredients.
Precautions
Precaution
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases.