Finasteride is a competitive inhibitor of human 5 a-reductase, an intracellular enzyme which metabolises testosterone into the more potent androgen, dihydrotestosterone (DHT). In benign prostatic hyperplasia (BPH), enlargement of the prostate gland is dependent upon the conversion of testosterone to DHT within the prostate. It is highly effective in reducing circulating and intraprostatic DHT. Finasteride has no affinity for the androgen receptor.
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