Mirtazapine is a centrally active presynaptic a2 -antagonist, which increases central noradrenergic and serotonergic neurotransmission. The enhancement of serotonergic neurotransmission is specifically mediated via 5-HT1 receptors, because 5-HT2 and 5-HT3 receptors are blocked by Mirtazapine. The histamine H1-antagonistic activity of Mirtazapine is associated with its sedative properties.
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