Oratane Softgel Capsules 20mg (1 Box = 3 Strips) (1 Strip = 10 Capsules)
Oratane Softgel Capsules 20mg (1 Box = 3 Strips) (1 Strip = 10 Capsules)
Oratane Softgel Capsules 20mg
Pack Size: 1 Box (3 Strips × 10 Softgel Capsules)
Generic Name: Isotretinoin
Dosage Form: Oral Softgel Capsules
Therapeutic Category: Oral Retinoid / Systemic Acne Treatment
Prescription Required: Yes
Oratane 20mg (Isotretinoin) – Oral Treatment for Severe Acne
Oratane Softgel Capsules 20mg contain Isotretinoin, a potent oral retinoid derived from Vitamin A. It is prescribed for the treatment of severe acne vulgaris, including nodular acne, cystic acne, conglobate acne, and acne at risk of permanent scarring, particularly in adults and adolescents who have not responded to conventional acne therapies such as topical treatments or oral antibiotics.
This systemic acne medication is considered one of the most effective treatments for persistent, treatment-resistant acne.
How Oratane (Isotretinoin) Works
Isotretinoin is a stereoisomer of all-trans retinoic acid (tretinoin). Although its exact mechanism is not fully understood, clinical studies show that it works by:
Suppressing sebaceous gland activity
Reducing the size of sebaceous (oil) glands
Decreasing excess sebum production
Preventing clogged pores
Reducing inflammation in the skin
By targeting the root causes of acne — excess oil, inflammation, and abnormal skin cell turnover — isotretinoin significantly improves severe acne and reduces the risk of acne scarring.
Indications
Oratane 20mg is indicated for:
Severe nodular acne
Cystic acne
Conglobate acne
Acne resistant to antibiotics or topical therapy
Acne with high risk of permanent scarring
Dosage & Administration
Adults and Adolescents:
Initial dose: 0.5 mg/kg body weight daily, taken with food (as a single dose or divided doses) for 4 weeks.
Maintenance dose: Adjusted between 0.1–1 mg/kg/day based on response for an additional 8–12 weeks.
Maximum cumulative dose: 150 mg/kg per course.
Repeat courses are generally not recommended.
Children: Not recommended.
Always follow your dermatologist’s instructions carefully.
Common Side Effects
Common (Up to 1 in 10 people)
Headache
Dry lips and skin (very common with isotretinoin therapy)
Increased cholesterol or triglycerides
Protein or blood in urine
Nasal dryness and mild nosebleeds
Sore throat or inflamed nasal passages
Increased susceptibility to infections
Allergic reactions (rash, itching)
Rare
Temporary hair loss (alopecia)
Very Rare
Night vision problems
Increased sensitivity to light (photosensitivity)
Blurred or distorted vision
Corneal opacity or cataracts
Seek medical attention if you experience severe allergic reactions or vision changes.
Drug Interactions
Do NOT take Oratane with:
Vitamin A supplements (risk of toxicity)
Tetracycline antibiotics
Other systemic retinoids
Topical keratolytic or exfoliating anti-acne treatments
Moisturizers and emollients are safe and recommended to manage dryness.
When Not to Use
Do NOT take Isotretinoin if:
You are pregnant or breastfeeding
You may become pregnant (strict pregnancy prevention required)
You are allergic to isotretinoin, peanuts, soya, or any ingredients
You have liver disease
You have very high cholesterol or triglyceride levels
Important Warnings & Precautions
Pregnancy Warning (Teratogenic Risk)
Isotretinoin can cause severe birth defects.
Strict contraception is required during treatment and for at least 1 month after stopping therapy.
Do not donate blood during treatment and for 1 month after stopping.
Mental Health Monitoring
Inform your doctor if you have a history of:
Depression
Mood disorders
Aggressive behavior
Suicidal thoughts
Mood changes have been reported during isotretinoin treatment.
Liver & Blood Monitoring
Regular blood tests are required to monitor:
Liver function (liver enzymes)
Cholesterol and triglycerides
Overall treatment safety
Your dose may be adjusted if abnormalities occur.
Specialist Supervision
Isotretinoin should only be prescribed and monitored by a dermatologist or physician experienced in systemic retinoid therapy.
Storage Instructions
Store at room temperature
Protect from direct light and heat
Keep out of reach of children